疏肝补肾调经汤联合克龄蒙治疗卵巢储备功能减退肝郁肾虚证临床研究

Clinical Study of Shugan Bushen Tiaojing Tang Combined with Climen for Diminished Ovarian Reserve with Syndrome of Liver Depression and Kidney Deficiency

目的:观察疏肝补肾调经汤联合克龄蒙治疗卵巢储备功能减退肝郁肾虚证的临床疗效。方法:选取96例卵巢储备功能减退肝郁肾虚证患者,按随机数字表法分为对照组和治疗组各48例。对照组从月经第5天起服用克龄蒙,治疗组在克龄蒙基础上加用疏肝补肾调经汤治疗。2组连续治疗3个月经周期。比较2组患者治疗前后的肝郁肾虚证症状评分、Kupperman评分及血清卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E_2)水平,比较2组的临床疗效。结果:治疗后,治疗组总有效率93.75%,高于对照组的77.08%,差异有统计学意义(P <0.05)。2组肝郁肾虚证症状(腰骶酸痛、头晕、胸胁胀满、精神不振)评分、Kupperman评分和血清FSH、LH水平均较治疗前下降(P <0.01),E_2水平高于治疗前(P <0.01);治疗组各项症状评分、Kupperman评分和血清FSH、LH水平均低于对照组(P <0.01),E2水平高于对照组(P <0.01)。结论:疏肝补肾调经汤联合克龄蒙治疗卵巢储备功能减退肝郁肾虚证疗效明显,调节患者体内激素水平可能是发挥疗效的途径之一。

Objective:To observe the clinical effect of Shugan Bushen Tiaojing tang combined with Climen for diminished ovarian reserve with syndrome of liver depression and kidney deficiency. Methods: Selected 96 cases of patients with diminished ovarian reserve with syndrome of liver depression and kidney deficiency,and divided them into the control group and the treatment group randomly, 48 cases in each group. The control group received Climen from the 5 th day ofmenstruation,while the treatment group additionally received Shugan Bushen Tiaojing tang. The treatment for both groups lasted for 3 menstrual cycles. Compared symptom scores of liver depression and kidney deficiency,Kupperman scores and levels of follicle stimulating hormone(FSH),luteinizing hormone(LH) and estradiol(E2) in serum of both groups before and after treatment,and compared the clinical effect in both groups. Results:After treatment,the total effective rate was 93.75% in the treatment group, being higher than 77.08% in the control group, difference being significant(P < 0.05). The symptom scores of liver depression and kidney deficiency(lumbosacral soreness, dizziness, distention in chest and hypochondrium,lassitude),Kupperman scores and levels of FSH and LH in serum of both groups were lower than those before treatment(P <0.01);the levels of E2 were higher than those before treatment(P < 0.01). Each symptom score,Kupperman scores and levels of FSH and LH in serum of the treatment group were lower than those in the control group(P < 0.01);the level of E2 was higher than that in the control group(P < 0.01). Conclusion: Shugan Bushen Tiaojing tang combined with Climen has significant clinical effect in treating diminished ovarian reserve with syndrome of liver depression and kidney deficiency, of which the therapeutic approach may be regulating the level of hormone in patients.