扶正康复合剂治疗肝郁气滞型肿瘤相关性抑郁临床研究

Clinical Study on Fuzheng Kangfu Mixture for Tumor-associated Depression of Liver Constraint and Qi Stagnation Type

目的:观察扶正康复合剂治疗肝郁气滞型肿瘤相关性抑郁临床疗效。方法:将诊断肿瘤后出现抑郁状态辨证为肝郁气滞型患者96例随机分为2组各48例。对照组予草酸艾司西酞普兰片进行治疗,观察组通过扶正康复合剂进行治疗,对比2组治疗效果。结果:治疗前,2组汉密顿抑郁量表(HAMD)评分比较,差异无统计学意义(P> 0.05);2组治疗后评分均出现一定程度降低,且观察组评分低于对照组(P <0.05)。观察组不良反应发生率为10.41%,对照组为37.50%,2组比较,差异有统计学意义(P <0.05)。观察组总有效率为93.75%,对照组77.08%,2组比较,差异有统计学意义(P <0.05)。与治疗前比较,2组治疗后白细胞介素-1α(IL-1α)、IL-1β水平升高(P <0.05),IL-6、肿瘤坏死因子-α(TNF-α)水平下降(P <0.05);观察组治疗后IL-1α、IL-1β、IL-6水平与对照组比较,差异有统计学意义(P <0.05)。观察组治疗后TNF-α水平与对照组比较,差异无统计学意义(P> 0.05)。结论:扶正康复合剂可有效改善肝郁气滞型肿瘤患者相关抑郁状态,可能与调节IL-1α、IL-1β、IL-6相关细胞因子水平有关。

Objective:To observe the clinical effect of Fuzheng Kangfu mixture for tumor-associated depression of liverconstraint and qi stagnation type.Methods:A total of 96 cases of patients who were differentiated into the liver constraint and qi stagnation type after diagnosis of tumor were divided into two groups randomly,48 cases in each group.The control group was treated with escitalopram oxalate tablets and the observation group was given Fuzheng Kangfu mixture.The therapeutic effect was compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of the score of Hamilton Depression Scale(HAMD)between the two groups(P>0.05);after treatment,the scores in both groups were decreased to some extent,and the one in the observation group was lower than that in the control group(P<0.05).The incidence of adverse reactions was 10.41%in the observation group and 37.50%in the control group,the difference being significant(P<0.05).The total effective rate was 93.75%in the observation group and 77.08%in the control group,the difference being significant(P<0.05).Compared with those before treatment respectively,the levels of interleukin-1α(IL-1α)and interleukin-1β(IL-1β)in the two groups were increased after treatment(P<0.05),and the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were decreased(P<0.05).The comparisons of levels of IL-1α,IL-1βand IL-6 between the two groups showed significance in the difference(P<0.05).There was no significant difference being found in the comparison of the level of TNF-αbetween the two groups(P>0.05).Conclusion:Fuzheng Kangfu mixture can effectively improve the depression state of patients with tumor of liver constraint and qi stagnation type,which may be related to the regulation of cytokines such as IL-1α,IL-1βand IL-6.