均匀设计法优化亲水性纳米硫化铜的合成工艺

Synthesis Technology Optimization of Hydrophilic Nanoscale Copper Sulfide by Uniform Design

目的:优化亲水性纳米硫化铜的合成工艺并对其进行表征。方法:采用水热法合成纳米硫化铜,并选用水溶性高分子聚乙烯吡咯烷酮对其进行修饰以改善水分散性和稳定性。以产率为主要指标,通过均匀试验设计优化纳米硫化铜的合成工艺。并对合成纳米硫化铜的光谱结构、水分散性、光热转化效率等方面进行表征。结果:纳米硫化铜的最佳合成工艺为:铜源与硫源的比例1∶1,反应温度130℃,反应时间13 h。其产率为(15. 70±0. 50)%。合成的纳米硫化铜为黑绿色粉末,水分散性及光热转化效率良好。其水溶液具有明显的浓度和时间依赖型的光热转换效应。结论:本试验可为下一步运用纳米硫化铜进行肿瘤的光热治疗研究提供一定的理论基础。

Objective:To optimize the synthesis technology of hydrophilic nanoscale copper sulfide and characterize it as well.Methods:The nanocrystalline copper sulfide was synthesized by a hydrothermal method,and the water soluble polyvinylpyrrolidone(PVP)was used to modify the nanocrystalline copper sulfide to improve the dispersibility and stability.With the yield as the main index,the synthesis process of nanoscale copper sulfide was optimized by uniform experimental design.The spectral structure,water dispersibility and photo-thermal conversion efficiency of the synthesized nanocrystalline copper sulfide were characterized.Results:The optimum synthesis conditions of nanoscale copper sulphide were as follows:the ratio of sulfur source to copper source was 1∶1,the temperature was 130℃,and the reaction time was 13 h.The yield was(15.70±0.50)%.The synthesized nanoscale sulfide copper was dark green powder with good water dispersibility and photothermal conversion efficiency.The aqueous solution had an obvious photothermal conversion effect in a concentration-and time-dependent manner.Conclusion:The study provides theoretical basis for the next application of nanoscale sulfide copper in photothermal therapy for tumors.