摘要
Metastasis is the leading cause of death in people with cancer. In the series of steps comprising metastasis process, mechanochemistry plays crucial roles. In this review, we introduced the mechanical factors in cancer cell metastasis, intracellular mechanical sensors and methods for measuring the mechanical forces of tumor cells. The recent researches on the contribution of mechanochemistry to metastasis and future perspectives were summarized.
Metastasis is the leading cause of death in people with cancer. In the series of steps comprising metastasis process, mechanochemistry plays crucial roles. In this review, we introduced the mechanical factors in cancer cell metastasis, intracellular mechanical sensors and methods for measuring the mechanical forces of tumor cells. The recent researches on the contribution of mechanochemistry to metastasis and future perspectives were summarized.
基金
supported by grants from the National Natural Science Foundation of China (Nos. 21778055, 21573250, 61501039)
Beijing Natural Science Foundation (Nos. L172048, 2162017)
Beijing Municipal Education Commission (No. KM201710015005)
the Chinese Academy of Sciences (Nos. QYZDB-SSW-SLH024, YZ201424)
the Program for Young Outstanding Scientists of ICCAS (No. Y41Z011)
