摘要
On the basis of the mild transformation of alkenyl triflates into alkynes promoted by LiCl, a one-pot protocol using alkenyl triflate precursors was developed for copper-mediated azide–alkyne cycloaddition. This protocol may provide an opportunity of sequentially click reactions for the construction of bifunctional probes in chemical biology studies.
On the basis of the mild transformation of alkenyl triflates into alkynes promoted by LiCl, a one-pot protocol using alkenyl triflate precursors was developed for copper-mediated azide–alkyne cycloaddition. This protocol may provide an opportunity of sequentially click reactions for the construction of bifunctional probes in chemical biology studies.
基金
Financial support was provided by the National Natural Science Foundation of China (Nos. 21525209, 21621002, 21772225, and 21761142003)
the Chinese Academy of Sciences (Strategic Priority Research Program (No. XDB20000000)
Key Research Program of Frontier Sciences (No. QYZDB-SSW-SLH040))
Shanghai Science and Technology Commission (Nos. 15JC1400400 and 17XD1404600)
the National Program for Support of TopNotch Young Professionals of China
the K. C. Wong Education Foundation
