GLP-1受体激动剂在肥胖相关性肾病中的作用机制

Mechanisms of GLP-1 receptor agonist in obesity-related glomerulopathy

肥胖相关性肾病(ORG)是一种由于肥胖及代谢综合征引起的胰岛素抵抗和慢性炎性反应而最终导致的肾脏损害。其发生机制比较复杂,可能与肾小球血流动力异常、炎性反应、氧化应激以及胰岛素抵抗等有关。近年来研究提示,胰高血糖素样肽-1受体激动剂对ORG有一定的保护作用。

Obesity-related glomerulopathy (0RG)is a renal lesion caused by insulin resistance and chronic inflammation caused by obesity and metabolic syndrome.The mechanisms are complex,especially glomerulus hemodynamic changes,inflammatory reaction,oxidative stress,insulin resistance.Recently,a number of studies have reported that glucagon-like peptide-1 receptor agonists have a protective effect on ORG.