内质网与线粒体相互作用在糖尿病心肌病中的作用

Roles of the interactions between endoplasmic reticulum and mitochondria in diabetic cardiomyopathy

糖尿病心肌病一种独立于高血压、冠心病等疾病的特异性心肌病变,是2型糖尿病患者致死的主要原因,但目前糖尿病心肌病的发病机制尚未完全阐明。内质网和线粒体是细胞内重要的细胞器,参与细胞各项生命活动,这两种细胞器间的相互作用与细胞内各种信号转导密切相关。最近一些研究表明,高糖可致细胞内内质网与线粒体连接松散,相互作用减弱,内质网与线粒体之间相互作用的变化可通过调节内质网应激、细胞缺氧应激、Ca^2+稳态等,参与糖尿病心肌病的发生、发展。

Diabetic cardiomyopathy is one of the main causes of death in patients with type 2 diabetes mellitus,which is independent of hypertension and coronary heart disease.However,the pathogenesis of diabetic cardiomyopathy has not been fully elucidated yet.Endoplasmic reticulum and mitochondria are important intracellular organelles involved in cellular activities.The interactions between these two organelles are closely correlated with various cell signaling pathways.Recent studies have shown that high glucose can lose the interaction between endoplasmic reticulum and mitochondria.The change of the interactions between endoplasmic reticulum and mitochondria are involved in the development of diabetic cardiomyopathy by regulating endoplasmic reticulum stress,cellular hypoxia stress,and Ca^2+homeostasis.