电针、埋线对单纯性肥胖患者血清瘦素、胰岛素影响的对比研究

Comparison of therapeutic effects of electroacupuncture and acupoint catgut embedding in reducing serum leptin and insulin levels in simple obesity patients

目的:探讨电针及埋线治疗单纯性肥胖症的作用机制,为临床治疗方法的应用提供依据。方法:90例单纯性肥胖患者随机分为电针组、埋线组,每组45例。电针组取天枢、大横、带脉等穴电针治疗,每次30min,隔日1次,共治疗30次;埋线组每次选取9～11个穴位交替埋线,10d1次,共治疗6次。观察两组患者治疗前后空腹血清瘦素(Leptin)、胰岛素(INS)水平变化,并分析其与体质量指数(BMI)变化的相关性。结果:治疗后,两组患者空腹血清Leptin、INS水平及BMI均较治疗前降低(P<0.01)。电针组、埋线组BMI变化与空腹血清Leptin、INS变化均呈正相关(P<0.01)。结论:埋线疗法同电针疗法均能够良性调节肥胖患者空腹血清Leptin、INS水平,纠正Leptin抵抗及INS抵抗。两种治疗方法中,BMI的变化均与Leptin、INS的变化呈正相关。

Objective To observe the therapeutic effect of electroacupuncture(EA)and acupoint catgut embedding in the treatment of simple obesity.Methods Simple obesity patients were randomized into EA group(7 men and 36 women,21-42 years in age)and catgut embedding group(4 men and 37 women,22-41 years in age).EA(4 Hz/20 Hz,a tolerable strength)was applied to main acupoints Zhongwan(CV12),bilateral Tianshu(ST25),Daheng(SP15),Daimai(GB26),Shuidao(ST28),Zhigou(TE6),Yinlingquan(SP9),Zusanli(ST36),Fenglong(ST40),and Sanyinjiao(SP6),and some auxiliary acupoints for 30 min,once every other day for 30 times.Subcutaneous catgut-embedment was performed in the same acupoints.Nine to 11 acupoints were used every time,once every 10 days for 6 times.Before and after the treatment,fasting serum leptin and insulin(INS)contents were detected by radioimmunoassay,and the correlation between the leptin,INS and the body mass index(BMI)was analyzed,respectively.Results Following the treatment,the serum leptin and INS concentrations and BMI in both groups were significantly decreased in comparison with those of their own pre-treatment(P<0.01).No significant differences were found between the two groups in the levels of serum leptin and INS after the treatment(P>0.05).There were positive correlations between the decreased BMI and serum leptin/INS contents in both EA and catgut embedding groups(P<0.01).Conclusion Both catgut embedding and EA interventions have a positive effect in reducing body weight of simple obesity patients,which may be related to its effects in down-regulating serum leptin and INS levels and in correcting leptin resistance and insulin resistance.