二白汤联合苯磺酸氨氯地平对高血压患者晨峰血压的影响

Effects of Erbai Decoction combined with amlodipine besylate on morning blood pressure surge in patients with hypertension

目的观察二白汤联合苯磺酸氨氯地平对高血压患者晨峰血压的影响。方法将72例高血压患者随机分为治疗组和对照组,每组36例;两组均予苯磺酸氨氯地平口服,治疗组同时加服二白汤。两组疗程均为28天,观察24 h平均收缩压(SBP)、24 h平均舒张压(DBP)、24 h血压达标率、晨峰血压控制率,以及改进SPIEGEL睡眠量表评分变化情况。结果 (1)两组治疗后24 h平均SBP和DBP均明显下降(P<0.05),但组间差异无统计学意义(P>0.05)。(2)治疗前后组内比较,两组血压晨峰值及SPIEGEL睡眠量表评分差异均有统计学意义(P<0.05);组间治疗后比较,血压晨峰值及SPIEGEL睡眠量表评分差异有统计意义(P<0.05)。(3)治疗组24 h平均血压达标率为88.9%、晨峰血压控制率为91.7%,对照组分别为67.7%、44.4%,治疗组明显优于对照组(P<0.05)。结论本观察结果提示,二白汤联合苯磺酸氨氯地平治疗高血压患者晨峰血压疗效明确,不仅24 h动态血压和晨峰血压控制良好,而且可以明显改善睡眠质量。

Objective To observe the effects of Erbai Decoction combined with amlodipine besylate on morning blood pressure surge in patients with hypertension.Methods 72 patients with hypertension were randomly assigned into the treatment group and the control group,36 patients in each group.Oral amlodipine besylate was given to patients in both groups and patients in the treatment group received Erbai Decoction in addition.The duration of treatment was 28 days in both groups.The 24 h mean systolic blood pressure(SBP),24 h mean diastolic blood pressure(DBP),24 h control rate of blood pressure,control rate of morning blood pressure surge and changes in scores on the modified SPIEGEL sleep scale were observed.Results(1)After treatment,24 h mean SBP and DBP decreased significantly in the groups(P<0.05),but with no statistically significant difference between the groups(P>0.05).(2)There were statistically significant differences in values of morning blood pressure surge and scores on the SPIEGEL sleep scale in the groups before and after treatment(P<0.05);and there were statistically significant differences in values of morning blood pressure surge and scores on the SPIEGEL sleep scale(P<0.05)between the groups after treatment(P<0.05).(3)The 24 h control rate of blood pressure and control rate of morning blood pressure surge were 88.9%and 91.7%respectively in the treatment group,and were 67.7%and 44.4%respectively in the control group,with the treatment group significantly superior to the control group(P<0.05).Conclusion The observation results indicate that Erbai Decoction combined with amlodipine besylate has definite efficacy in the treatment of hypertension,as the 24 h ambulatory blood pressure and morning blood pressure surge are well controlled,and the quality of sleep is improved remarkably.