105例肾移植住院患者临床用药合理性分析

Rationality Analysis of Clinical Medication in 105 In-patients withRenal Transplantation

目的:了解医院肾移植住院患者的用药使用情况,并分析其合理性,为临床合理用药提供参考。方法:从计算机系统里抽取医院2016年1月—2017年12月间肾移植病历105份,分析其患者的性别、年龄、平均住院天数、疾病类型、用药品种等。结果:医院肾移植患者所用药物主要集中在免疫抑制剂(42.56%,主要以他克莫司或者环孢素为基础的三联治疗方案)、抗感染药物(9.23%,主要以第3、4代头孢菌素、碳青霉烯类药物、糖肽类药物和抗真菌药物为主)、降压药物(27.47%)和抗排斥反应药物(1.37%),未发现不合理用药情况。结论:医院肾移植患者用药基本合理,但仍需加强药学监护,进一步优化联合用药方案,以保障患者用药安全和有效。

Objective:To find out the use of drugs in hospitalized renal transplant patients in our hospital, and toanalyze its rationality, so as to provide reference for clinical rational drug use. Methods:105 patients of kidney trans-plants in our hospital from 2016-01 to 2017-12 were extracted from the computer system. A retrospective analysis of thepatients’ gender, age, average number of days of hospitalization, type of disease, and variety of drugs was performed. Re-sults:The drugs used in renal transplant patients in our hospital mainly are on immunosuppressive agents(42.56%, main-ly based on the triple therapy regimen of tacrolimus or cyclosporine), anti-infective drugs(9.23%, mainly in the third andfourth generation cephalosporins Carcinogens, carbapenems, glycopeptides, and antifungals), antihypertensives(27.47%), and anti-rejection drugs(1.37%). No unreasonable drug use was found. Conclusion:The use of drugs in kid-ney transplant patients in our hospital is basically reasonable, but it is still necessary to strengthen the supervision of thepatients and further to optimize the combination regimen so as to ensure safe and effective medication for patients.