高龄非酒精性脂肪肝患者与血清25-羟维生素D水平的相关性研究

Correlation between level of serum 25-hydroxyvitamin D and elderly patients with non-alcoholic fatty liver disease

目的探讨高龄非酒精性脂肪肝(NAFLD)患者血清25-羟维生素D[25-(OH)D]水平变化及与NAFLD发生发展的相关性。方法选择在北京大学人民医院老年科住院的老年患者434例,年龄为(80.05±8.69)岁,分为NAFLD组(n=138例),无NAFLD组(n=296例),检测血清25-(OH)D水平。结果 NAFLD组血清25-(OH)D水平[(33.43,66.01)nmol/L]显著低于无NAFLD组[(41.55,17.53)nmol/L](P<0.05);在NAFLD组中维生素D缺乏的患者比例明显升高(P<0.05)。结论 NAFLD组的血清25-(OH)D水平低于无NAFLD组。血清25-(OH)D水平与老年NAFLD显著相关。

[Objective]To investigate change of serum 25-hydroxyvitamin D[25-(OH)D] in elderly patients with non-alcoholic fatty liver disease(NAFLD),explore its correlation with the occurrence and development of NAFLD.[Methods] 434 elderly patients in Geriatrics Department of People’s Hospital of Peking University were selected,whose average age was(80.05±8.69) years old,and divided into the NAFLD group(n =138) and normal group(n =296). The level of serum 25-(OH)D was detected.[Results]The level of serum 25-(OH)D in the NAFLD group[(33.43,66.01)nmol/L] was significantly lower than that in the normal group[(41.55,17.53)nmol/L](P<0.05). The proportion of patients with vitamin D deficiency in NAFLD group was significantly increased(P<0.05).[Conclusion]The level of serum 25-(OH)D in the NAFLD group is lower than the normal group. The level of serum 25-(OH)D is significantly associated with elderly NAFLD.