利胆汤联合异甘草酸镁治疗肝癌射频消融术后肝损伤的疗效观察

Effect of Lidan decoction combined with magnesium isoglycyrrhizinate in the treatment of liver injury after radiofrequency ablation for liver cancer

目的观察利胆汤联合异甘草酸镁治疗肝癌射频消融术(RFA)后肝损伤的疗效。方法选取海阳市人民医院2015年2月至2016年2月收治的肝癌RFA后肝损伤患者60例为研究对象,电脑随机分为观察组、对照组各30例,分别实施利胆汤联合异甘草酸镁以及常规药物治疗,观察两组临床疗效。结果治疗后,观察组的总有效率为90.00%(27/30),高于对照组的66.67%(20/30)(χ^2=4.811,P<0.05);观察组白蛋白(39.02±0.91)g/L、直接胆红素(6.31±0.71)μmol/L、天门冬氨酸氨基转移酶(59.12±5.81)U/L、丙氨酸氨基转氨酶(54.18±8.31)U/L,与对照组差异均有统计学意义(t=7.199、6.211、6.440、7.928,均P<0.05)。结论利胆汤联合异甘草酸镁治疗肝癌RFA后肝损伤有显著效果。

Objective To observe the effect of Lidan decoction combined with magnesium isoglycyrrhizinate in the treatment of liver injury after radiofrequency ablation(RFA) for liver cancer. Methods From February 2015 to February 2016, 60 liver cancer patients with liver injury after RFA in the People's Hospital of Haiyang were selected in this study.The patients were randomly divided into the observation group and control group, with 30 cases in each group.The observation group was given Lidan decoction combined with magnesium isoglycyrrhizinate, and the control group was given conventional therapy. Results After treatment, the total effective rate of the observation group was 90.00%(27/30), which was higher than 66.67%(20/30) of the control group (χ^2=4.811, P<0.05). The levels of albumin (ALB), direct bilirubin (DBIL), AST, ALT in the observation group were (39.02±0.91)g/L, (6.31±0.71)μmol/L, (59.12±5.81)U/L, (54.18±8.31)U/L, respectively, the differences were statistically significant between the two groups (t=7.199, 6.211, 6.440, 7.928, all P<0.05). Conclusion Lidan decoction combined with magnesium isoglycyrrhizinate is effective in treating liver cancer patients with liver injury after RFA.