卡介菌多糖核酸联合雷公藤多苷对慢性荨麻疹患者炎性因子和T细胞亚群的影响

Effects of BCG polysaccharide nucleotides combined with Tripterygium wilfordii polyglycosides on inflammatory factors and T cell subsets in patients with chronic urticaria

目的探讨卡介菌多糖核酸联合雷公藤多苷对慢性荨麻疹患者炎性因子和T细胞亚群的影响。方法选择古交市中心医院2015年1月至2017年1月收治的慢性荨麻疹患者84例,采用随机数字表法分为观察组42例、对照组42例。对照组采用常规治疗,观察组采用卡介菌多糖核酸联合雷公藤多苷治疗。观察两组白细胞介素2(IL-2)、IL-4、IL-10及外周血γ干扰素(IFN-γ)、T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)的变化,比较两组临床疗效。结果治疗后,观察组总有效率高于对照组[97.62%(41/42)比85.71%(36/42)](χ^2=3.896,P<0.05);观察组IL-2、IFN-γ水平均高于对照组[(314.54±45.47)ng/L比(285.04±46.84)ng/L,(310.25±32.80)ng/L比(265.14±28.11)ng/L](t=2.928、6.767,均P<0.05);观察组IL-4、IL-10水平均低于对照组[(18.65±3.14)ng/L比(26.09±4.52)ng/L,(57.65±6.34)ng/L比(63.74±6.82)ng/L](t=8.760、4.238,均P<0.05);观察组CD4^+、CD4^+/CD8^+水平均高于对照组[(39.86±6.96)%比(34.44±7.06)%,(1.60±0.14)比(1.34±0.15)](t=3.543、8.212,均P<0.05);观察组CD8^+水平低于对照组[(24.34±3.99)%比(27.24±4.33)%](t=3.191,P<0.05)。结论卡介菌多糖核酸联合雷公藤多苷治疗慢性荨麻疹可有效上调患者外周血IFN-γ和IL-2水平,降低IL-4、IL-10水平,改善患者炎性因子水平和T细胞亚群(CD4^+、CD8^+和CD4^+/CD8^+)水平,疗效安全可靠,值得应用推广。

Objective To study the effect of BCG polysaccharide nucleic acid combined with Tripterygium wilfordii polyglycoside(TWP) on inflammatory factors and T cell subsets in patients with chronic urticaria. Methods From January 2015 to January 2017, 84 patients of chronic urticaria in Gujiao Central Hospital were selected in the research.The patients were randomly divided into observation group and control group, with 42 cases in each group.The control group was treated with conventional therapy, and the observation group was treated with BCG polysaccharide nucleic acid combined with TWP.The levels of IL-2, IL-4, IL-10, peripheral blood interferon-γ(IFN-γ), T cell subsets(CD4^+ , CD8^+ , CD4^+ /CD8^+ ) were observed, and the clinical efficacy was compared. Results After treatment, the total effective rate of the observation group was higher than that of the control group[41(97.62%) vs.36(85.71%)](χ2=3.896, P<0.05). The levels of IL-2 and IFN-γ in the observation group were higher than those in the control group[(314.54±45.47)ng/L vs.(285.04±46.84)ng/L, (310.25±32.80)ng/L vs.(265.14±28.11)ng/L](t=2.928, 6.767, all P<0.05). The levels of IL-4 and IL-10 in the observation group were lower than those in the control group[(18.65±3.14)ng/L vs.(26.09±4.52)ng/L, (57.65±6.34)ng/L vs.(63.74±6.82)ng/L](t=8.760, 4.238, all P<0.05). The levels of CD4^+ , CD4^+ /CD8^+ in the observation group were higher than those in the control group[(39.86±6.96)% vs.(34.44±7.06)%, (1.60±0.14) vs.(1.34±0.15)](t=3.543, 8.212, all P<0.05). The level of CD8^+ in the observation group was lower than that in the control group[(24.34±3.99)% vs.(27.24±4.33)%](t=3.191, P<0.05). Conclusion BCG polysaccharide nucleic acid combined with TWP in the treatment of chronic urticaria can effectively increase peripheral blood IFN-γ and IL-2 levels, decrease IL-4, IL-10 levels, improve levels of inflammatory cytokines and T cell subsets(CD4^+ , CD8^+ and CD4^+ /CD8^+ ), the efficacy is safe and reliable, it is worthy of application and promotion.