2-芳基取代的吡啶并[2,3-d]嘧啶衍生物的合成

Synthesis of 2-Aryl Substituted Pyridio [2,3-d] pyrimidine Derivatives

以2-氨基-3-氰基吡啶为起始原料,先制备得到3-氨甲基吡啶-2-胺,在氯化亚铜、三乙烯二胺和2,2,6,6-四甲基-1-哌啶氧催化体系下,得到几种2-芳基取代的吡啶并[2,3-d]嘧啶衍生物。同时考察了反应温度、反应溶剂、反应时间对反应收率的影响。该方法具有操作简便,后处理简单、反应收率高的特点。目标化合物结构均经1HNMR、13CNMR和LCMS确证。

Using 2-amino-3-cyanylpyridine as starting material,the 3-aminomethylene-2-amine was first prepared. Several 2-aryl substituted pyridio [2,3-d] pyrimidine derivatives were designed and synthesized,by using Cu Cl/DABCO/TEMPO as the catalysts.The effects of reaction temperature,solvent and time on reaction yield were also investigated.This method has the advantages of simple operation,simple post-treatment and high reaction rate. The structures of the compounds were confirmed by1 HNMR、13 CNMR and LC-MS.