细胞外基质重建规律衍变与梗死后缺血心肌纤维化发生

Evolvement of reconstruction rules about extracellular matrix in fibrogenesis after myocardial infarction

细胞外基质(extracellular matrix,ECM)是梗死后缺血心肌纤维化发生的主要病理产物,随着病程进展而出现重建规律的衍变:炎症期坏死胶原基质瓦解,临时基质网络形成;增殖期基质细胞蛋白富集,肌成纤维细胞活化;修复期胶原基质瘢痕稳定,基质蛋白时序清除。靶向干预ECM降解、优化调节ECM分泌能够为心脏再生提供骨架支撑、维持心脏结构完整和舒缩韧性的同时,防止异常ECM重建带来的心脏功能衰竭。

Extracellular matrix (ECM)is the main pathological product during fibrogenesis in ischemic myocardium after myocardial infarction.The progression and reconstruction rules of ECM develop along with different periods of the disease:in the inflammatory stage.A temporary matrix network forms with the degradation of original collagen matrix.In the proliferative stage,the enrichment of matricellular proteins activates myofibroblasts In the reparative stage,a stable collagen matrix network is established and temporary matrix proteins are removed punctually.Targeting the degradation of ECM and optimizing the secretion of ECM proteins will provide a complete skeleton support for cardiac regeneration,maintain the integrated heart structure and diastolic toughness,and then prevent heart function failure owing to abnormal ECM reconstruction.