miR-223在心血管疾病中的研究进展

Research progress of miR-223 in cardiovascular diseases

心血管疾病(cardiovascular disease,CVD)是目前危害人类生命健康的最重要的疾病,其中以冠心病(coronrayheart disease,CHD)为甚。微小RNA(microRNA、miRNA)是一类在转录后水平调控基因表达及功能的小分子非编码RNA,参与多种疾病的病理生理过程。微小RNA-223(miR-223)是一种髓系特异性miRNA,在血小板、血浆、内皮细胞中含量丰富,可通过调控血小板及内皮细胞的多种基因表达及功能,参与CVD发生发展,如动脉粥样硬化、血栓形成,心肌代谢,血管生成等多个环节。本文就miR-223在CVD中的作用做一综述。

Cardiovascular disease is one of the most important diseases that endanger people's life,and coronary heart disease is the most prevalent worldwide.MicroRNAs are a class of small,noncoding RNAs regulating the expression and functions of target genes posttranscriptionally and participating in the pathophysiological process of various diseases.As a myeloid specific miRNA,MicroRNA-223 is abundant in platelets,plasma and endothelial cells,and is involved in the development of many cardiovascular diseases. The present investigation on miR-223 functions in cardiovascular diseases contributes to the understanding of the oathogenesis,diagnosis,treatment and prognosis of cardiovascular diseases.