T细胞参与心肌缺血/再灌注损伤的研究进展

Role of T cells in myocardial ischemia reperfusion injury

心肌缺血/再灌注损伤(MI/RI)是治疗心肌梗死过程中的并发症之一,中性粒细胞、巨噬细胞等固有免疫细胞引起的炎性反应是导致MI/RI的重要原因。众多免疫细胞如何在MI/RI中发挥作用是目前研究的热点问题。近年来,越来越多的研究表明T细胞在MI/RI中发挥重要作用。本文将阐述T细胞在MI/RI中的作用及机制的研究进展,并分析目前存在的问题及发展方向。

Myocardial ischemia-reperfusion injury is one of the complications in the treatment of myocardial infarction.Inflammatory responses caused by innate immune cells such as neutrophils and macrophages are important reasons for myocardial ischemia-reperfusion injury.The role of many kinds of immune cells in myocardial reperfusion injury has become a hot research topic.In recent years,more and more studies have demonstrated that adaptive immune cells,especially T cells,play an important role in myocardial ischemia- reperfusion injury.This article reviews the research on the role and mechanism of T cells involved in myocardial ischemia-reperfusion injury and analyzes existing problems and future directions.