摘要
Junctophilin(JPH) 2可以"连接和沟通"心肌细胞横管与肌质网。在心肌肥厚、心衰、心房颤动等心脏疾病中,均存在JPH2表达下降或突变的现象。调控JPH2的途径有3条:calpain,微管密度和miR-24。直接上调JPH2或间接干预JPH2的调控途径均能够保护心肌细胞,有利于心脏功能改善,故JPH2可能成为治疗多种心脏疾病的新靶点。
Junctophilin-2 (JPH2)can connect and communicate T-tubule to sarcoplasmic reticulum in cardiomyocytes.JPH2 mutation or down-regulation has been found in hearts from hypertrophic cardiomyopathy,heart failure,and atrial fibrillation.Calpain,rnicrotubules,and miRNA-24 are all involved in the regulation of JPH2 in cardiomyocytes.Up-regulation of JPH2 directly or indirectly protects cardiomyocytes, which may be beneficial for the repair of certain cardiac disease processes.
作者
许翠
王婷
顾欣悦
李盛村
XU Cui;WANG Ting;GU Xin-yue;LI Sheng-cun(Faculty of Medical and Health,Lishui University,Lishui 323000,Zhejiang,China;Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325000,Zhengjiang, China)
出处
《心脏杂志》
CAS
2019年第1期103-106,共4页
Chinese Heart Journal
基金
浙江省新苗人才计划项目资助(2017R431007)
国家级大学生创新创业训练计划项目资助(201710352006)
国家自然科学基金项目资助(81802243)
关键词
JPH2
心脏疾病
机制
Junctophilin-2
cardiac disease
mechanism
