痰热清注射液对老年重症肺炎并发脓毒症患者HMGB1水平的影响

Effect of Tanreqing injection on HMGB1 levels in elderly patients with severe pneumonia complicated with sepsis

目的:探讨痰热清注射液对老年重症肺炎相关性脓毒症患者高迁移率蛋白B1水平的影响。方法:选择2017-01—2018-03期间就诊于我院的78例老年重症肺炎并发脓毒症患者,依据随机数字表法分为治疗组和对照组,两组均给予脓毒症集束化治疗,治疗组加用痰热清注射液20ml静脉滴注,1次/d,连续使用7d。观察两组患者治疗前后血清HMGB1、PCT、急性生理和慢性健康状况评估(APACHE)Ⅱ评分变化。结果:两组患者入科后的血清HMGB1、PCT及APACHEⅡ评分比较差异均无统计学意义(均P>0.05);治疗组治疗前血清HMGB1、PCT及APACHEⅡ评分显著高于治疗后(P<0.05);治疗后对照组血清HMGB1、PCT及APACHEⅡ评分高于治疗组(均P<0.05);治疗组治疗前,患者血清HMGB1水平与PCT水平呈正相关(r=0.979,P<0.05);HMGB1与APACHEⅡ评分呈正相关(r=0.973,P<0.05);PCT水平与APACHEⅡ评分呈正相关(r=0.978,P<0.05);治疗组治疗后,患者血清HMGB1水平与PCT水平呈正相关(r=0.972,P<0.05);HMGB1与APACHEⅡ评分呈正相关(r=0.981,P <0.05);PCT水平与APACHEⅡ评分呈正相关(r=0.973,P <0.05)。结论:痰热清可改善老年重症肺炎并发脓毒症患者病情,降低血清HMGB1、PCT水平及APACHEⅡ评分,从而改善预后。

Objective:To investigate the effect of Tanreqing injection on the levels of high mobility protein B1 in elderly patients with severe pneumonia-related sepsis.Method:Seventy-eight elderly patients with severe pneumonia complicated with sepsis who were treated in our hospital from January 2017 to March 2018 were selected and divided into treatment group and control group according to random number table method.Both groups were treated with sepsis cluster therapy.The treatment group was treated with 20 ml Tanreqing injection intravenously once a day for 7 consecutive days.The changes of serum HMGB1,PCT,APACHEⅡ scores were observed before and after treatment.Result:There was no significant difference in serum HMGB1,PCT and APACHEⅡscores between the two groups at admission(all P>0.05);the scores of serum HMGB1,PCT and APACHEⅡbefore treatment in the treatment group were significantly higher than those after treatment(P<0.05);the scores of serum HMGB1,PCT and APACHEⅡin the control group were higher than those in the treatment group after treatment(all P<0.05).Before treatment,serum HMGB1 level of treatment group was positively correlated with PCT level(r=0.979,P<0.05);HMGB1 was positively correlated with APACHEⅡscore(r=0.973,P<0.05);PCT level was positively correlated with APACHEⅡ score(r=0.978,P<0.05);after treatment,serum HMGB1 level of treatment group was positively correlated with PCT level(r=0.972,P<0.05);HMGB1 was positively correlated with APACHEⅡ score(r=0.981,P<0.05);PCT level was positively correlated with APACHEⅡ score(r=0.973,P<0.05).Conclusion:Tanreqing reduced the levels of serum HMGB1,PCT and APACHE II score of elderly patients with severe pneumonia complicated with sepsis,thereby improved the prognosis.