摘要
环状RNA(circRNA)具有与线性RNA完全不同的共价闭环结构,在哺乳动物组织中普遍表达, 在心血管领域,circRNA已被证明具有抗心血管衰老、与RNA结合蛋白结合作为microRNA海绵、作为生物标志物及作为疾病治疗的靶点等多种功能。本文综述了近年来环状RNA与心血管衰老及circRNA在心血管病作用的研究进展。
CircRNA have covalent closed-loop structures completely different from linear RNA,which are widely expressed in mammalian tissues.In the field of cardiovascular diseases,circRNA have been proven to have anti-cardiovascular aging,combining with RNA binding proteins as microRNA sponges,serving as biomarkers and as targets for disease treatment,etc.This paper reviews the recent progress in the research on the role of circRNA in cardiovascular aging and diseases.
作者
凌浩
张艳秋
杨闯
肖钰
廉瑞
宋春莉
LING Hao;ZHANG Yan-qiu;]YANG Chuang;XIAO Yu;LIAN Rui;SONG Chun-li(Department of Cardiovascular Medicine,Second Hospital of Jilin University,Changehun 130012,China)
出处
《中国心血管病研究》
CAS
2019年第2期104-107,共4页
Chinese Journal of Cardiovascular Research
基金
吉林省教育厅十三五科学技术研究项目(JJKH20180104KJ)
吉林省财政厅卫生专项项目(2017年)
吉林省新型冠脉支架科技创新中心(JKFC2017250).