帕金森病患者黑质在磁共振成像中表现的研究进展

Research Progress of Magnetic Resonance Imaging for Substantia Nigra Imaging in Parkinson's Disease

中脑黑质多巴胺能神经元选择性变性死亡是帕金森病特征性的病理改变,随着磁共振成像(MRI)技术的不断发展,越来越多的研究表明MRI可以清晰显示中脑黑质的结构及其病理变化,因此MRI技术有望实现对帕金森病的精准诊断、病情评估及疾病监测。文中重点阐述MRI新技术在帕金森病黑质显像应用的研究进展。

The selectively apoptosis of dopaminergic neurons in substantia nigra( SN) is one of the most important pathologic changes in Parkinson’s disease( PD). With the development of MRI,more and more researches have shown that MRI can offer an efficient way to show the changes of SN,so as to achieve the purpose of accurate diagnosis and disease surveillance. The advances in SN imaging of PD with MRI were reviewed.