症状词与疾病身份词Stroop范式对精神分裂症患者执行功能障碍的筛查价值

Practical value of Stroop task of symptomatic words and identity-related words for screening executive dysfunction in schizophrenia

目的探讨症状词与疾病身份词的情绪Stroop范式作为精神分裂症执行功能障碍筛查工具的可行性。方法选取稳定期精神分裂症患者(患者组)65例,正常对照组62例。采用经典Stroop范式和症状词与疾病身份词的情绪Stroop范式,比较患者组与对照组在症状与疾病身份词Stroop范式上的反应时差异,并分析其对两组被试的区分程度。结果患者组在症状与疾病身份词Stroop范式上的反应时均长于对照组[症状词Stroop范式:(1206.65±476.39)ms和(916.01±395.85)ms;疾病身份词Stroop范式:(1256.22±630.18)ms和(927.85±419.98)ms,t=6.46,6.01,均P<0.01]。ROC曲线显示,在最佳阈值处,负性症状词的灵敏度89%,特异度57%;精神分裂症身份词的灵敏度81%,特异度66%。结论症状词与疾病身份词的情绪Stroop范式可作为筛查精神分裂症患者执行功能障碍的客观、有效的工具。

Objective To explore the practical value of Stroop task of symptomatic words and identity-related words for screening executive dysfunction in schizophrenia. Methods Sixty-five patients with schizophrenia in clinical remission and sixty-two healthy controls were recruited in this trial.Patients and controls completed the Stroop task of symptomatic words and identity-related words.Analyze and compare the difference of reaction time between the two groups on the two stroop paradigms and further analyze the degree of discrimination of the two stroop paradigme. Results The reaction time of schizophrenic patients was longer than that of healthy controls in both symptom-word Stroop task ((1 206.65±476.39)ms vs (916.01±395.85)ms, t=6.46, P<0.001), and identity-word Stroop task((1 256.22±630.18)ms vs (927.85±419.98)ms, t=6.01, P<0.01). The sensitivity and specificity were obtained by Receiver Operating Characteristic curves in symptom-word Stroop task (89% and 57%, respectively) and identity-word Stroop task (81% and 66%, respectively). Conclusion Symptom-word Stroop task and identity-word Stroop task showed moderate diagnostic value for the identification executive dysfunction in patients with schizophrenia.