锌指蛋白GLi在肝细胞癌的发生、发展及治疗中的研究进展

Research progress on zinc finger protein GLi in development and treatment of hepatocellular carcinoma

肝细胞癌是常见的恶性肿瘤之一,其发病率和病死率一直居高不下。目前肝细胞癌的首选治疗方法为手术治疗及肝移植,但5年生存率仍较低,且由于肝细胞癌起病隐匿,大多数患者初期均无特殊表现,确诊时已经处于终末期,失去手术机会。Hh通路在肿瘤的发生、发展中发挥关键作用,锌指蛋白GLi作为Hh通路中的关键转录因子在肿瘤的发生中起着重要作用。同时锌指蛋白GLi可通过诱导上皮-间质转化的发生,从而在肝细胞癌的侵袭转移过程中发挥关键作用。此外锌指蛋白GLi还与多种肿瘤相关因子相互作用从而影响肝细胞癌的发生、发展。本文就锌指蛋白GLi在肝细胞癌发生、发展及治疗中的作用作一综述。

Hepatocellular carcinoma is one of the most common malignant tumors in the world, and its morbidity and mortality have been high. The current preferred treatment for hepatocellular carcinoma is surgical treatment and liver transplantation, but the 5year survival rate is still low. Due to the insidious onset of hepatocellular carcinoma, most patients have no special manifestations at the initial stage. At the time of diagnosis, they are already in the terminal stage and lose the opportunity of surgery.The Hh pathway plays a key role in the development of tumors. The zinc finger protein GLi plays an important role in tumorigenesis as a key transcription factor in the Hh pathway.At the same time, zinc finger protein GLi can play a key role in the invasion and metastasis of hepatocellular carcinoma by inducing epithelialmesenchymal transition. In addition, the zinc finger protein GLi also interacts with various tumorrelated factors to affect the occurrence and development and treatment of hepatocellular carcinoma. This article reviews the role of zinc finger protein GLi in the development and treatment of hepatocellular carcinoma.