脓毒症多器官功能障碍发病机制研究

The research on the pathogenesis of multiple organ dysfunction in sepsis

脓毒症的特征是机体对感染的反应失调而导致的危及生命的器官功能障碍,目前研究表明器官功能损伤程度与脓毒症患者的预后直接相关。探讨脓毒症多器官功能障碍的机制并采取有效的干预措施是脓毒症研究的重要方向。本文从炎症反应、内皮细胞损伤及微循环障碍、凝血功能异常、细胞凋亡、线粒体受损、器官之间交互作用等方面对目前与脓毒症多器官功能障碍相关的发病机制的研究做一阐述。

Sepsis is characterized by Life-threatening organ dysfunction induced by a disorder response to infection,current studies have shown that degree of organ dysfunction is directly related to the prognosis of patients with sepsis.To explore the mechanism of multiple organ dysfunction in sepsis and to take effective intervention measures is an important direction of sepsis research.In this paper,the current pathogenesis of multiple organ dysfunction associated with sepsis was reviewed from the aspects of endothelial cell injury in inflammatory response,microcirculation disorder,coagulation dysfunction,cell apoptosis,mitochondrial damage,and interaction between damaged organs.