探究早期无创呼吸支持结合暂时性气管插管PS应用治疗新生儿呼吸窘迫综合征失败的相关高危因素

To explore the related risk factors of failure of early noninvasive respiratory support combined with temporary endotracheal intubation for the treatment of neonatal respiratory distress syndrome

目的分析早期无创呼吸支持结合暂时性气管插管PS应用治疗新生儿呼吸窘迫综合征失败的相关高危因素。方法抽取2016年1月—2017年12月在我院出生、并确诊为呼吸窘迫综合征的240例新生儿,根据患儿的临床疗效分为显效组和无效组,每组各120例,回顾分析所有新生儿的临床资料。结果显效组和无效组患儿的胎龄、阴道分娩、出生体重、产前激素应用、RDS分级、PDA、PaCO2、a/APO2等存在显著差异(P<0.05)。结论 INSURE治疗新生儿呼吸窘迫综合征失败的相关性高危因素主要和胎龄、出生体重、PaCO2以及动脉肺泡氧分压比值有关。

Objective To analyze the risk factors of the failure of early noninvasive respiratory support combined with temporary endotracheal intubation in the treatment of neonatal respiratory distress syndrome.Methods 240 cases of neonates born in our hospital during January 2016 and December 2016,those were diagnosed neonatal respiratory distress syndrome,were selected.Patients were divided into effective group and ineffective group according to the patient ’ s clinical curative effect, with 120 cases in each group.We retrospectively analyzed the clinical data of all the newborn babies.Results There were significant differences in gestational age,vaginal delivery,birth weight,prenatal hormone application,RDS classification,PDA,PaCO2,and a/APO2 between the effective group and the invalid group( P<0.05).Conclusions The risk factors for the failure of INSURE in the treatment of neonatal respiratory distress syndrome are mainly related to gestational age,birth weight,PaCO2 and arterial alveolar oxygen partial pressure ratio.