趋化因子及其受体在非小细胞肺癌中的发生发展及治疗的研究进展

Study progress of the role of chemokines and their receptors in the development and treatment of non-small cell lung cancer

趋化因子是一类由多种细胞产生的具有一定趋化能力的小分子量蛋白。趋化因子与其相应的受体结合通过多种信号转导通路参与非小细胞肺癌的发生和发展、血管生成和凋亡、侵袭和转移,并在非小细胞肺癌的诊断和预后中起着至关重要的作用,一些趋化因子及其受体亦可作为肺癌治疗的潜在靶点。

Chemokines are a class of low molecular weight proteins produced by various cells with chemotactic ability.Chemokines and their corresponding receptors are associated with a variety of signal transduction pathways involved in occurrence and development, angiogenesis and apoptosis, invasion and metastasis of non-small cell lung cancer( NSCLC),and play a vital role in the diagnosis and prognosis of NSCLC.Some chemokines and their receptors may also be used as potential targets for the treatment of NSCLC.