糖化白蛋白与动脉硬化相关性研究

Correlation between glycated albumin and arterial stiffness

目的:探讨体检人群糖化白蛋白(GA)水平与动脉硬化的相关性。方法:以肱踝脉搏波传导速度(baPWV)≥1 400 cm/s为标准,将参加常规体检的741人,分为动脉硬化组和正常对照组,测定血清GA及其他生化指标,应用动脉硬化诊断仪测量臂踝脉搏波传导速度(baPWV)。采用Spearman相关分析及多重线性回归分析GA和baPWV的相关性。结果:动脉硬化组的年龄、BMI、血压、血脂、尿酸、肌酐、baPWV、空腹血糖及GA均显著高于对照组(P<0.05)。Spearman相关分析显示GA与baPWV呈正相关(P<0.05)。多重线性回归分析显示,调整其他混杂因素后仍与baPWV独立正相关(P<0.05)。结论:体检人群中血清GA水平与动脉硬化正相关,且独立于其他危险因素。健康体检中测定GA对普通人群动脉硬化的预防及早期监测具有意义。

Objective:To explore the correlation between glycated albumin(GA) and arterial stiffness.Methods:Based on brachial-ankle pulse wave velocity(baPWV) ≥ 1 400 cm/s,741 subjects who participated in the routine physical examination were divided into arterial stifness group and control group.Serum GA and baPWV were measured.Spearman correlation and multivariate linear regression analysis were used to evaluate the relationship between GA and baPWV.Results:Age,BMI,blood pressure,blood lipids,uric acid,creatinine,baPWV,fasting blood glucose and GA were significantly higher in arterial stifness group than in control group(P<0.05).GA was positively associated with baPWV(P<0.05).After adjustment for the above confounding factors,GA was still positively associated with baPWV(P<0.05).Conclusion:Serum GA levels were positively correlated with arterial stiffness and were independent of other risk factors.The determination of GA may help detect the development of arterial stiffness in the health screening population.