长非编码RNA TUG1与消化系统肿瘤

Long non-conding RNA TUG1 and digestive system cancers

牛磺酸上调基因1(taurine-upregulated gene1,TUG1)是新近发现的致癌性长非编码RNA(lncRNA),其在各种消化系统恶性肿瘤组织和细胞株中过度表达,包括食管癌、胃癌、肝癌、胆道肿瘤、胰腺癌和结直肠癌。研究表明高表达的TUG1参与肿瘤细胞增殖、凋亡、迁移和侵袭过程,且与恶性肿瘤患者的临床病理特征及预后相关,表明lncRNATUG1可能是消化系统肿瘤中可行的肿瘤标志物或治疗靶点。

Taurine-upregulated gene 1 (TUG1) is a recently identified oncogenic long non-coding RNA (lncRNA), that is overexpressed in various digestive system tumor tissues and cell lines, including esophageal cancer, gastric cancer, liver cancer, cholangiocarcinoma and biliary tract cancer, pancreatic cancer and colorectal cancer. Studies have shown that TUG1 participates in tumor cells proliferation, apoptosis, migration and invasion, and high expression of TUG1 is associated with clinicopathological features and prognosis of cancer patients, suggesting that lncRNA TUG1 is likely represents a feasible biomarker or therapeutic target in human digestive system cancers.