《人血白蛋白用于肝硬化治疗的快速建议指南》解读

Expert consensus on Rapid Advice Guidelines for the Pharmacological Management of Human Albumin in Patients with Liver Cirrhosis

为了促进人血白蛋白的临床合理应用,中国药学会医院药学专业委员会联合中华医学会肝病学分会共同制订了国内首部基于循证医学的《人血白蛋白用于肝硬化治疗的快速建议指南》。在指南制订过程中,充分考虑了指南推荐意见在临床实践中的可行性,从白蛋白的血浆浓度、低蛋白血症所造成的功能障碍以及病理生理异常诸方面,制订了人血白蛋白的应用原则和推荐剂量,以期为临床医师及药师合理应用人血白蛋白提供基本规范和具体指导。本文将主要对指南形成的推荐意见、证据总结以及推荐说明进行解读。

In order to implement appropriate HA use,the Chinese Hospital Association,Chinese Society of Clinical Pharmacy and Chinese Society of Hepatology,Chinese Medical Association have developed evidence-based,Rapid Advice Guidelines for the Pharmacological Management of HA in Patients with Liver Cirrhosis.In the guideline development process,the feasibility of the guideline recommendations in clinical practice was fully considered.From the plasma concentration of albumin,dysfunction and pathophysiological abnormalities caused by hypoproteinemia,application principles and recommended dosages are intended to provide basic specifications and specific guidance for clinicians and pharmacists to rationally apply human albumin.This article will mainly explain the recommendations,evidence summary and recommendation descriptions formed by the guideline.