大株红景天联合抗生素治疗子宫内膜炎疗效观察

Therapeutic effect of Rhodiola sachalinensis combined with antibiotics on endometritis

目的单纯抗生素治疗子宫内膜炎治疗时间长,见效慢,且后期容易出现耐药性;大株红景天是一种活血化瘀的中药制剂,其有效成分可清除体内自由基。本研究旨在探讨大株红景天联合抗生素治疗子宫内膜炎的效果及对相关细胞因子的影响。方法选取宝安区中心医院2016-01-01-2017-12-31收治的180例子宫内膜炎患者作为研究对象,根据入院治疗方法不同分为观察组和对照组,各90例,对照组采用常规抗生素治疗,观察组采用大株红景天联合抗生素治疗,分析比较两组临床疗效及相关细胞因子水平。结果观察组总有效率为94.44%(85/90),优于对照组的82.22%(74/90),χ2=17.61,P=0.02;观察组复发率为10.00%(9/90),低于对照组的24.44%(22/90),χ2=10.52,P=0.04;观察组不良反应发生率为2.22%(2/90),与对照组的3.33%(3/90),比较差异无统计学意义,χ2=0.01,P=0.25。治疗后,观察组血清TNF-α水平为(65.91±11.72)pg/mL,低于对照组的(96.73±13.72)pg/mL,t=24.82,P=0.01;观察组IL-6为(121.22±24.63)pg/mL,低于对照组的(187.23±32.62)pg/mL,t=17.31,P=0.04;观察组IL-1β为(1.32±0.23)ng/mL,低于对照组的(2.14±0.32)ng/mL,t=20.42,P=0.03,观察组子宫内膜厚度为(5.23±0.82)mm,高于对照组的(3.93±0.62)mm,t=22.22,P=0.02。结论大株红景天联合抗生素治疗子宫内膜炎临床疗效显著,可有效缓解患者炎症反应,提高治愈率。

OBJECTIVE Treatment with simple antibiotics for endometritis is lengthy and is prone to drug resistance.Rhodiola sachalinensis is a traditional Chinese medicine preparation for promoting blood circulation and removing blood stasis.Its active ingredients can reduce the oxidative damage of free radicals in the body.This study aims to investigate the efficacy of Rhodiola sachalinensis combined with antibiotics in the treatment of endometritis and its impact on therapeutic indicators.METHODS A total of 180 patients with endometritis admitted to Baoan Central Hospital from January 1,2016 to December 31,2017 were selected as the subjects of study.According to the different treatment methods,the patients were divided into observation group and control group,90 cases in each group.The control group was treated with conventional antibiotics,and the observation group was treated with Rhodiola combined with antibiotics.The clinical efficacy and related cytokine levels of the two groups were analyzed and compared.RESULTS The total effective rate of the observation group was 94.44%(85/90),which was higher than that of the control group 82.22%(74/90),χ^2=17.61,P=0.02.The recurrence of the observation group was 10.00%(9/90),which was lower than that of the control group 24.44%(22/90),χ^2=10.52,P=0.04.The incidence of adverse reactions was 2.22%(2/90)in the observation group and 3.33%(3/90)in the control group.The difference was not statistically significant,χ^2=0.01,P=0.25.After treatment,the serum TNF-αof the observation group was(65.91±11.72)pg/ml,lower than that of the control group(96.73±13.72)pg/ml.The difference was statistically significant,t=24.82,P=0.01.The IL-6of the observation group was(121.22±24.63)pg/ml,lower than that of the control group(187.23±32.62)pg/ml.The difference was statistically significant,t=17.31,P=0.04.The IL-1βof the observation group was(1.32±0.23)ng/ml,lower than that of the control group(2.14±0.32)ng/ml.The difference was statistically significant,t=20.42,P=0.03.The endometrial thickness of the observation group was(5.23±0.82)mm,which was thicker than that of the control group(3.92±0.62)mm,t=22.22,P=0.02.CONCLUSION Rhodiola sachalinensis combined antibiotics in the treatment of endometritis has a significant clinical effect,which effectively relieves the patient’s inflammatory response and improves the cure rate.