血清皮质醇检测在顽固性原发性失眠症患者中的意义

Significance of serum cortisol in patients with refractory primary insomnia

目的:探讨分析血清皮质醇检测在顽固性原发性失眠症患者中的意义.方法:选取2017年3月~2018年4月于我院精神科门诊确诊的28例顽固性原发性失眠症患者为实验组,选取同时间内我院职工健康体检的28例健康体检者为对照组,对比两组患者的皮质醇水平,并测定匹兹堡睡眠质量指数评估睡眠状况.结果:实验组清晨8点的血清皮质醇含量为(489.54±75.64) nmol/L,显著高于对照组清晨皮质醇含量(327.39±60.31) nmol/L;实验组睡眠障碍、睡眠时间、睡眠质量、睡眠效率、入睡时间、催眠药物和日间功能等7项评分均显著高于对照组,实验组PSQI评分的总分也显著高于对照组,差异均具有统计学意义(P<0.05).结论:顽固性原发性失眠症患者体内皮质醇含量增高,且与患者睡眠质量呈正相关,具有临床参考意义,值得临床推广.

Objective: To investigate the significance of serum cortisol in patients with refractory primary insomnia. Methods: Twenty—eight patients with refractory primary insomnia diagnosed in the psychiatric outpatient department of our hosp让al from March, 2017 to April, 2018 were selected as the experimental group. Twenty—eight healthy persons who underwent physical examination were selected as the control group. The cortisol levels ofthe two groups were compared and Pittsburgh Sleep Quality Index (PSI) was measured to evaluate the sleep status. Results: The serum cortisol level in the experimental group was (489.54±75.64) nmol/L at 8 am, which was significantly higher than that in the control group (327.39 ±60.31) nmol/L. The scores of sleep disorder, sleep time, sleep quality, sleep efficiency, sleep time, hypnotics and daytime function in the experimental group were significantly higher than those in the control group. The total score ofthe PSQI score in the experimental group was also significantly higher than that in the control group and the difference was statistically significant (P<0.05) . Conclusion: Cortisol levels in patients with refractory primary insomnia are higher than healthy persons and positively correlated with sleep quality. It has some clinical reference significance and deserve clinical expansion.