复方丹参滴丸治疗糖尿病视网膜病变的临床研究

Clinical Effect of Compound Danshen(Salvia Miltiorrhiza)Pills in the Treatment of Diabetic Retinopathy

【目的】 探讨复方丹参滴丸治疗糖尿病视网膜病变(DR)的临床效果。【方法】 选取2015年3月至2017年10月本院收治的106例DR患者的临床资料,按随机数表法分为观察组和对照组,每组各53例。对照组患者予降糖、酸碱平衡等糖尿病常规治疗,观察组在对照组的基础上口服复方丹参滴丸治疗。观察两组患者的疗效,视野灰度、血管瘤体积、出血斑面积、黄斑厚度以及血清白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、高敏C反应蛋白(hs-CRP)、血浆内皮素-1(ET-1)、血管内皮生长因子(VEGF)、活性氧(ROS),分光光度计法检测超氧化物歧化酶(SOD)和丙二醛(MDA)水平。【结果】 观察组总有效率为90.57%(48/53),显高于对照组的77.36%(41/53),差异有统计学意义(P<0.05)。两组患者的视野灰度及血管瘤体积、出血斑面积、黄斑厚度及血清hs-CRP、IL-6、TNF-α、ET-1、VEGF、ROS、MDA水平较治疗前均明显降低,SOD较治疗前明显升高,且观察组改善幅度较对照组更加显著,差异均有统计学意义(P<0.05)。治疗期间两组患者均未发生明显的药物不良反应。【结论】 复方丹参滴丸治疗DR可提高临床疗效,改善视野缺损症状,下调炎性指标,改善血管内皮功能,缓解氧化应激状态,且安全性良好,值得在临床中推广应用。

【Objective】 To investigate the clinical effect of compound salvia miltiorrhiza(Danshen) pills in the treatment of diabetic retinopathy(DR). 【Methods】 The clinical data of 106 patients with DR from March 2015 to October 2017 were divided into observation group and control group with 53 cases in each group. The patients in the control group were treated with hypoglycemic, acid-base balance, and the observation group was treated with compound salvia miltiorrhiza pills on the basis of the control group. The therapeutic effect, visual field grayscale, hemangioma volume, macular area, macular thickness, serum interleukin-6 (IL-6), tumor necrosis factor (TNF-α),high sensitivity C-reactive protein (hs-CRP), plasma endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), reactive oxygen (ROS) were observed. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) (MDA) were measured by spectrophotometer.【Results】 The total effective rate was 90.57% (48 / 53) in the observation group and 77.36% (41/53) in the control group (P<0.05). The visual field grayscale, hemangioma volume, macular area, macular thickness, serum hs-CRP, IL-6,TNF-αand ET-1, VEGF, ROS, MDA levels were significantly lower in both groups than before treatment, and SOD was significantly higher than that before treatment. The improvement in the observation group was more significant than that in the control group, and the difference was statistically significant (P<0.05). There were no obvious adverse drug reactions in both groups during treatment.【Conclusion】 Compound salvia miltiorrhiza (Danshen) pills can improve the clinical efficacy, improve the symptoms of visual field defect, down-regulate the inflammatory index, improve vascular endothelial function, alleviate oxidative stress state, and the safety is good. It is worth popularizing in clinical application.