HDAC2、IL-17A在COPD患者血清中的表达水平及其临床意义

Serum HDAC2 and IL-17A Levels in Patients with Chronic Obstructive Pulmonary Disease and Their Clinical Significance

【目的】 探讨组蛋白脱乙酰基酶(HDAC2)、白细胞介素17A(IL-17A)在慢性阻塞性肺疾病(COPD)患者血清中的表达水平及其临床意义。【方法】 选取2017年8月至2018年5月在本院诊治的COPD患者40例,并选取同期在本院接受体检的健康成年人40例作为对照。比较两组HDAC2、IL-17A水平、肺功能和血气水平,分析COPD患者HDAC2、IL-17A水平与肺功能和血气的相关性。【结果】 COPD组患者的HDAC2、pH和动脉血氧分压(PaO2)水平显著低于对照组(P<0.05);IL-17A 、动脉血二氧化碳分压(PaCO2)水平显著高于对照组(P<0.05)。COPD组患者的用力肺活量(FVC)、第一秒用力呼气量占用力肺活量比值(FEV1/FVC)、最大呼气中段流量(MMEF)和最大呼气流量(PEF)水平显著低于对照组(P<0.05)。COPD患者的HDAC2水平与PaCO2呈负相关,与FEV1/FVC、FVC、MMEF、PEF、pH、PaO2水平正相关;IL-17A水平与PaCO2水平正相关,与FEV1/FVC、FVC、MMEF、PEF、PH、PaO2水平负相关。【结论】 COPD患者HDAC2水平较低,IL-17A水平较高,且与肺功能和血气指标密切相关。

【Objective】 To investigate the levels of histone deacetylase (HDAC2) and interleukin-17A (IL-17A) in patients with chronic obstructive pulmonary disease (COPD) and to analyze the clinical significance. 【Methods】 Patients with COPD who were treated in our hospital from August 2017 to May 2018 were selected as the study subjects (COPD group,n=40), and healthy adults who received physical examination in the same period were selected as the control group (n=40). The levels of HDAC2, IL-17A, pulmonary function and blood gas were compared between the two groups, and the correlation of the levels of HDAC2 and IL-17A with pulmonary function and blood gas was analyzed. 【Results】 The levels of HDAC 2,pH and arterial partial pressure of oxygen (PaO2) in the COPD group were lower than those in the control group (P<0.05), and the levels of IL-17A and arterial partial pressure of carbon dioxide (PaCO2) were higher than those in the control group (P<0.05). The forced vital capacity (FVC), FEV1/FVC, maximum expiratory mid-flow (MMEF) and maximum expiratory flow (PEF) were significantly lower in the COPD group than in the control group (P<0.05). The level of HDAC2 in COPD patients was negatively correlated with PaCO2, and positively correlated with FEV1/FVC, FVC, MMEF, PEF, PH and PaO2 levels. The level of IL-17A was positively correlated with PaCO2 level, and negatively correlated with FEV1/FVC, FVC, MMEF, PEF, PH and PaO2 levels. 【Conclusion】 The level of HDAC2 is lower and level of IL-17A is higher in COPD patients. They are closely related to lung function and blood gas index.