烟草依赖慢性阻塞性肺疾病基因多态性研究进展

Study on genetic polymorphism of tobacco dependent chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)是以慢性气流受限为主要特征,在易患基因的基础上各种危险因素相互作用的基因异质性疾病。吸烟是COPD发病机制中最常见的致病因素,本综述将主要讨论在吸烟的作用下COPD基因的多态性和易感性,为烟草依赖COPD高危人群的筛选、早期预防和治疗提供理论依据。

Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a heterogeneous disease in which various risk factors interact on the basis of susceptible genes.Smoking is the most common pathogenic factor in the pathogenesis of COPD.This review mainly investigated the effect of smoking on the polymorphism and susceptibility of COPD gene, and provided a theoretical basis for the screening, early prevention and treatment in tobacco-dependent COPD high-risk population.