DDAH基因多态性与糖尿病关系的研究进展

Research progress in relationship between dimethylarginine dimethylaminohydrolase gene polymorphism and diabetes mellitus

糖尿病是由多基因遗传和环境因素共同作用的慢性疾病。随着分子生物实验的深入研究,糖尿病与基因的关系愈加显著。二甲基精氨酸二甲胺水解酶(DDAH)作为水解人体内非对称性二甲基精氨酸(ADMA)的主要酶,被证实其基因多态性影响ADMA的表达,与其有关的内皮功能损害是糖尿病及血管并发症的重要原因,故DDAH多态性变异可作为糖尿病风险的预测因子。本文对DDAH基因多态性与糖尿病及血管并发症的相关性进行综述。

Diabetes mellitus is a chronic disease caused by multiple genetic and environmental factors. The relationship between diabetes mellitus and genes becomes more prominent during the advancement of molecular biology. It is well known that dimethylarginine dimethylaminohydrolase(DDAH)is the main enzyme for asymmetric dimethylarginine(ADMA)in human body. In recent years,a large number of studies have confirmed that DDAH gene polymorphism affects ADMA expression,and it is associated with endothelial dysfunction,which is an important cause of diabetes mellitus and its vascular complications. So,it is suggested that DDAH polymorphism could be used as a predictor for diabetes mellitus risk. Here,we reviewed the association between DDAH gene polymorphism and diabetes mellitus and its vascular complications.