摘要
目的:分析血清高迁移率族蛋白1水平检测在乙型重型肝炎中的价值。方法:焦作市第三人民医院收治的91例乙型病毒性肝炎患者依据疾病类型不同分为2组,慢性组45例,重型组46例,另选取同期体检健康者44例为健康组,对比三组患者HMGB1及肝生化指标水平。结果:重型组HMGB1、TBil、AST及ALT水平均高于慢性组及健康组,Alb及PTA水平明显低于慢性组及健康组,慢性组HMGB1、TBil、AST及ALT水平均高于健康组,慢性组Alb、PTA水平低于健康组(P<0.05)。结论:血清HMGB1水平越高,患者肝功能损伤越严重,HMGB1指标水平可作为重型乙型肝炎患者治疗的新靶点。
Objective:To analyze the value of serum high mobility group box-1 levels in the detection of severe hepatitis B.Methods:91 patients with hepatitis B admitted to the Third People's Hospital of Jiaozuo City were divided into two groups according to the type of disease.45 patients in the chronic group.46 cases of heavy group.Another 44 healthy people who were in the same period were selected as the health group.The levels of HMGB1 and liver biochemical indicators were compared between the three groups.Results:The HMGB1,TBil,AST and ALT levels in the severe group were higher than those in the chronic group and the healthy group.The levels of Alb and PTA were significantly lower than those of the chronic and healthy groups.The HMGB 1,TBil,AST and ALT levels in the chronic group were higher than those in the healthy group.The levels of Alb and PTA in the chronic group were lower than those in the healthy group (P<0.05).Conclusion:The higher the serum HMGB1 level,the more severe the liver function damage in patients.The HMGB1 indicator level can be used as a new target for the treatment of patients with severe hepatitis B.
作者
薛海树
郭洪涛
XUE Haishu;GUO Hongtao(Xiuwu County Center for Disease Control and Prevention,Henan Xiuwu 454350,China;Third People's Hospital of Jiaozuo City,Henan Jiaozuo 454150,China)
出处
《中医药临床杂志》
2019年第2期205-207,共3页
Clinical Journal of Traditional Chinese Medicine