顺铂联合化疗治疗卵巢恶性生殖细胞肿瘤

Cisplatin-Based Chemotherapy in the Management of Germ Cell Tumors of Ovary

目的:探讨卵巢恶性生殖细胞肿瘤的治疗疗效及复发患者二线治疗。方法:对我院1958年11月～1998年12月312例卵巢恶性肿瘤中的154例接受顺铂方案化疗的卵巢恶性生殖细胞肿瘤结果进行分析。结果:154例卵巢恶性生殖细胞肿瘤的总生存率为74.7%,初治患者(Ⅰ～Ⅲ期)92例,5年生存率为92.2%,其中66例(71.7%)保留生育功能,19例已正常生育20次。复发转移62例,5年生存率51.1%,8例保留生育功能。结论:为了提高卵巢恶性生殖细胞肿瘤生存率,首次手术时应正确分期,术后及时采用当前标准BEP方案作为一线化疗,连续3～6疗程。对复发患者,根据以往治疗情况尽早选用有效的二线方案化疗,有利于提高生存率。

Objective:To evaluate the efficacy of cisplatin-based combination chemotherapy in patients with ovarian germ cell tumors and second-line chemotherapy for patients with recur -rent germ cell tumors.Methods:A total of154patients with ovarian germ cell tumors from1985-1998were analysed retrospectively.All patients received cisplatin-based chemotherapy as a part of their first-line or salvage therapy at cancer hospital.Results:The overall5-year survival rate was74.7%and the mean5-year survival rate of patients with stage I-III disease was92.2%and that for the patients with recurrent disease was51.1%.Seventy-four cases preserved fertility,22patients attempted conception after chemotherapy and19of whom were successful.A total of20living births were documented.Conclusion:To improve the prognosis of malignant germ cell tumor of ovary,at initial operation,a comprehensive surgical staging procedure is performed.BEP is the most effective first-line regimen at present.Current patients receive early second-line chemotherapy can increase the survival of patients.