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缺血预适应对缺血再灌注肾脏粘附分子表达的影响 被引量：6

Effects of renal ischemic precoditioning on the expression of ICAM-1 and E-selectin after ischemia-reprefusion injury
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摘要 目的　探讨缺血预适应对肾脏ICAM 1、E 选择素表达的影响。方法　大鼠 4个循环的 8min缺血 + 5min再灌注缺血预适应模型 ,免疫组化观察在体肾脏粘附分子ICAM 1、E 选择素的表达。结果　缺血预适应后肾脏ICAM 1、E 选择素的表达显著降低 ,局部髓过氧化物酶活性降低。结论　缺血预适应可抑制缺血再灌注损伤后肾脏ICAM 1、E 选择素的表达 ,减少局部白细胞浸润 。 Objective To study the effects of renal ischemic precoditioning on the expression of ICAM 1 and E selectin after ischemia reprefusion injury. Methods The kidney ischemic preconditioning was induced by 4 circles of left renal ischemia (8 min) separated by reperfusion (5 min) before ischemia reperfusion injury, the expression of ICAM 1 and E selectin were observed by immunohistochemistry. Results The kidney ICAM 1 and E selectin expression were significantly decreased after ischemic preconditioning, the myeloperoxidase reactivity were decreased too. Conclusions Kidney ischemic preconditioning could inhibit the expression of ICAM 1 and E selectin and reduce neutrophil infiltration in kidney after ischemia reperfusion injury.
作者 刘宏 吴雄飞 金锡御
机构地区 第三军医大学附属西南医院全军泌尿中心肾科
出处 《第三军医大学学报》 CAS CSCD 北大核心 2002年第3期289-291,共3页 Journal of Third Military Medical University
基金 国家自然科学基金资助项目 ( 39870 34 8)
关键词 肾脏 缺血预适应 粘附分子 再灌注损伤 ICAM-1 E-选择素 影响 kidney ischemic preconditioning adhesion molecules
分类号 R692 [医药卫生—泌尿科学]
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参考文献8

  • 1[1]Murry C E, Jennings R B, Reimer K A. Preconditioning with i schemia: a delay of lethal cell injury in ischemic myocardium[J].Circulation ,1986,74(5):1 124-1 136.
  • 2[2]Turman M A, Bates C M. Susceptibility of human proximal tubular cel ls to hypoxia: effect of hypoxic preconditioning and comparison to glomerular ce lls[J].Renal Failure,1997,19(1):47-60.
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同被引文献26

  • 1张艳敏,郭勇,冯志强,王琼.胰岛素对肾小管细胞缺血再灌注损伤的保护作用[J].山东大学学报（医学版）,2005,43(8):741-744. 被引量：3
  • 2冷向锋,王德昌,张秋,冯永强,王坤,肖虎,霍然,薛文君.严重烧伤大鼠肾脏细胞凋亡及其机制的研究[J].中华烧伤杂志,2006,22(2):121-123. 被引量：3
  • 3Murry CE, Jenings RB, Reimjer KA, et al. Preconditioning with ischemia: a delay of lethal cellular injury in ischemic myocardium.Circulation, 1986,74:1124-1136.
  • 4Islam CF, Mathie RT, Dinneen MD, et al. Ischaemia-reperfusion injury in the rat kidney: the effect of preconditioning. Br J Urol,1997,79: 842-847.
  • 5Lee HT, Emala CW, et al. Protein kinase C and G(i/o) proteins are involved in adenosine and ischemic preconditioning mediated renal protection. J Am Soc Nephrol, 2001, 12: 233-240.
  • 6Furuichi K, Wada T, Iwata Y, et al. Administration of FR167653,a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant, 2002, 17:399-407.
  • 7Jeremiah JM, Saulo K. Differential effects of ACE and AT1 receptor inhibition on chemoattractant and adhesion molecular synthesis.Am J Physiol Renal Physiol, 1998, 274: F580-F586.
  • 8Ogawa T, Mimura Y, Kaminishi M. Renal denervation abolishes the protective effects of ischaemic preconditioning on function and haemodynamics in ischaemia-reperfused rat kidneys. Acta Physiol Scand, 2002, 174: 291-297.
  • 9Bonventre JV. Renal ischemic preconditioning. Curr Opin Nephrol Hypertens, 2002, 11: 43-48.
  • 10Kelly KJ, Williams WW, Colvin RB, et al. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest, 1996, 97: 1056-1063.

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第三军医大学学报
2002年 第3期

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