细胞间粘附分子-1在哮喘患儿气道上皮细胞的表达及临床意义

Expression and the clinical significance of intercellular adhension molecule-1 in airway epithelial cells from asthmatic children

目的 了解细胞间粘附分子 1(intercellularadhensionmolecule 1,ICAM 1)在哮喘患儿气道炎症中的作用。方法 通过纤维支气管镜活检气道粘膜 ,分别进行病理、免疫组织化学及原位杂交检查 ,观察气道粘膜炎症和ICAM 1及其mRNA在哮喘患儿气道上皮细胞的表达 ,并与对照儿童比较。结果 哮喘患儿存在气道粘膜炎症 ,ICAM 1及其mRNA在哮喘患儿气道上皮细胞的表达增加。结论 ICAM

Objective To observe the role of intercellular adhension molecule-1(ICAM-1)in airway inflammation of asthmatic children.Methods The biopsic mucosa were obtained by Fiberoptic Bronchoscopy,and the expression of ICAM-1 and mRNA in airway epithelial cells from asthmatic children were observed respectively by pathological immunohistochemistry and in situ hybridization and compared with the contrast group.Results The expression of ICAM-1 and mRNA will increase in airway epithelial cells from asthmatic children if there is airway inflammation in asthmatic children.Conclusion ICAM-1 expression may play a role in airway inflammation in asthmatic children.