霉酚酸酯等新三联在肾移植术后的近期疗效

Application of Mycophenolate Mofetil ( MMF ) after the Kidney Transplantation

目的:观察霉酚酸酯（MMF）在预防肾移植术后急性排斥及肺部感染的情况。方法:89例肾移植后应用皮质激素（Perd）,环孢素（CsA）,MMF（或）硫唑嘌呤（Aza）三联免疫抑制剂治疗,其中分成MMF组52例,Aza组37例,MMF组中适当减少CsA用量。结果:临床观察3个月中,急性排斥（AR）发生率MMF组7.7％（4/52）,Aza组16.2％（6/37）,肺部感染率MMF组13.5％（7/52）,Aza组21.6％（8/37）,两者之间存在明显差异（P<0.05）。结论:MMF组方案对减少AR发生率与并发肺部感染率有一定作用。

: To the MMFs effect on preventing the acute rejection(AR) and the pulmonary infection after kidney transplantantion. Methods: 89 patients were randomly divided into two groups.One was treated with MMF , while the other was treated with azathioprine (Aza).Both were accompanied with the treatment of cyclosporin A and cortico steroids. The dosage of Cyclospoin A was moderately reduced in the MMF group. Results: Among 52 patients in the MMF group, 4(7. 7% )were found the AR and 7(13.5%) pulmonary infection, while amony 37 patient in Aza group, 6(16.2% )were found AR and 8(21.6%) pulmonary infection. There was significant difference between two groups (P<0.05). Conclusion: MMF can prevent acute rejection and infection pulmonary after the kidney transplantation