Graves病外周血细胞免疫功能的变化

The Clinical study of T lymphoeyte subset and HLA-DR of peripheral blood in Graves disease patients

免疫调节网络失衡是 Graves病 (GD)发生、发展的重要因素之一。应用改良的碱性磷酸酶抗磷酸酶桥联酶标染色技术 (APAAP法 )测定了 10 2例 GD患者及 43例正常对照者外周血 T淋巴细胞亚群及 HL A - DR抗原的表达。结果表明 GD患者外周血 CD+8升高 ,HL A- DR抗原表达率增高 ,DR抗原表达增加与 FT3、CD+8增高有关。

The immunregulator net dysbalance is a important factor in Graves disease occurring and developing.T lymphocyte subset and HLA DR antigen in 102 GD patients with different thyroid function and 43 normal controls were examined by APAAP method.The results showed that CD + 8 and HLA DR in peripheral blood of GD patients were increased.Following the level of FT 3 and CD + 8 increasing,the expression of HLA DR in peripheral blood is high