尿白蛋白和β_2微球蛋白的联合测定在糖尿病肾病早期的诊断价值

Diagnostic Value of the Combinative Measuring of Urinary Albumin and β_2-microglubin in Diabetes Nephritis

目的 探讨尿白蛋白和 β2 微球蛋白的联合测定在糖尿病肾病早期的诊断价值。方法 采用放射免疫方法测定 98例DM患者 2 4小时尿中ALB和 β2 -MG。结果 DM患者尿ALB和 β2 -MG显著增高 (其中病程在 3～ 5年者增幅较小 ,5年以上者增幅较大 ) ;且 2者有明显的正相关关系 (r =0 6 5 4,P <0 0 1)。与正常对照组有显著差异 (P <0 0 1)。结论 尿ALB和 β2 -MG可以作为DM患者早期肾损害的灵敏指标。

Objective To study the diagnostic value of the combinative measuring of urinary albumin and β 2-microglubin in diabetes nephritis Methods The urinary albumin and β 2-microglubin in 98 DM patients were detected with radiation immunity method Results The urinary albumin and β 2-microglubin in DM patients were significant higher than the normal group (The breadth of increasing of the 3～5 year diabetes was smaller than those which were more than 5 years), and there was a clear positive relationship between the two guidelines( r =0 654, P<0 01) There was significant di fference between the normal group( P <0 01) Conclusion The urinary albumin and β 2-microglubin were sensitive index for the early injury in kidney of DM