大剂量顺铂腹腔持续冲洗化疗治疗卵巢癌的临床研究

Intraperitoneal continual washing chemotherapy with large dosage platinum on ovarian carcinoma

为提高卵巢癌的化疗效果 ,提高患者的生存率 ,设计了一种新型的化疗方法—持续腹腔冲洗化疗法。将 2 9例卵巢上皮癌患者随机分为持续腹腔冲洗组 (WIP组 ,14例 )和常规腹腔化疗组 (CIP组 ,15例 )。 WIP组腹腔化疗时首先注入生理盐水 2 0 0 0 m l+顺铂 (CDDP) 70 mg/m2后放开出液管 ,继以生理盐水 5 0 0 ml+CDDP17.5 mg/m2进行持续腹腔冲洗化疗 ,每 2小时 1瓶 ,进出液保持平衡 ,治疗总时间为 12小时 ,CDDP总入量为 175 m g/m2 。结果 WIP组 CR+PR率为 4 3% ,CIP组为 13% ,P<0 .0 5 ;尿 β2 M在两组的变化具有统计学意义(P<0 .0 5 )。由于加强了管理 ,WIP组毒副作用并未增加 (P>0 .0 5 ) ,患者也可耐受。

To evaluate the new methods of intraperitoneal continual washing chemotherapy (WIP) from two sides managing the patients and preventing, the side effects' of CDDP In WIP group,after given NS 2000ml +CDDP 70mg/m 2 ,the out tube was to be turn on Continual washing chemotherapy was begin with NS 500ml+CDDP 17 5mg/m 2 q2h The liquid amount both in up and lower tube was maintain to be balanced The total washing time and amount of CDDP was 12h and 175mg/m 2 respectively The results showed that(CR+PR) rate in WIP and CIP group were 43% and 13% respectively,the difference was significant(P<0 05) β 2M also showed significant decreasing(P<0 05) These suggest that the new methods intraperitoneal continual washing chemotherapy can be improved the prognosis of advanced ovarin carcinoma in the base of increing the dose of cDDP It's side effects is not increased