肺心病患者肾上腺髓质素测定的临床意义及其相关因素分析

The Clinical Significance of Determination of Adrenal Medulla in Patients with Chronic Cor Pulmonale and Analysis of Its Relevant Factors

为探讨肾上腺髓质素 (ADM )在慢性肺心病发生发展中的作用 ,以及吸烟、缺氧、肺功能等因素对肾上腺髓质素的影响 ,测定 63例慢性肺心病患者急性发作期和缓解期的ADM ,并用多元回归分析方法分析患者年龄、病程、吸烟和肺功能等因素对ADM的影响。发现慢性肺心病患者急性发作期及缓解期ADM比正常人显著升高 (P <0 .0 0 1)。一秒钟用力呼气容积 (FEV1 )与动脉氧分压PaO2 、吸烟、阻塞性通气功能障碍、缺氧是影响ADM水平的因素。结果表明 ,慢性肺心病患者ADM高于正常人 ,且ADM升高与病情的严重程度有关。

In order to find the function of adrenal medulla in the development of chronic cor pulmonale and the effect of smoking, anoxia and lung′s work on adrenal medulla, we determined adrenal medulla in 63 patients with acute cor pulmonale(Group A) and 60 controls (Group B). We tried to find out the effect of the patients′ age, course of disease, history of smoking, malfunction of lung on adrenal medulla by multiple regressive analysis. Adrenal medulla is significantly higher in Group A than that of in Group B( P <0.001). The ratio of forced expiratory volume in one second to vital capacity and the arterial oxygen pressure PaO 2 both contribute to the conclusion that smoking is an independent factor to affect the adrenal medulla. Our study shows that the adrenal medulla in patients with cor pulmanale is higher than that of normal people, and that the level of adrenal medulla is dependent on the degree of seriousness of the disease, obstructive ventilatory disturbance and anoxia.ndependentfactortoaffectt