妊娠期肝内胆汁郁积症患者血清甘胆酸检测的临床价值

Clinical Significance of Serum Glycochlicacid Detection in Diagnosis of Intrahepatic Cholestasis of Pregnancy

妊娠期肝内胆汁郁积症 (ICP)是发生于妊娠中、晚期的疾病 ,该病对围产儿影响较大。为进一步探讨血清甘胆酸 (CG)对ICP的临床诊断价值 ,用放射免疫法对孕妇、ICP患者检测了血清CG值 ,并与丙氨酸转氨酶(ALT)和碱性磷酸酶 (ALP)进行了对比分析 ,结果是 :ICP组CG值明显高于妊娠组 ,差异非常显著 (P <0 .0 1) ,其阳性率为 10 0 % ;ICP组ALT阳性率为 80 % ,ALP阳性率为 40 %。因此 ,血清CG是目前诊断ICP最敏感的血清学指标。

Intrahepatic cholestasis of pregnancy(ICP) occurred in the middle and later phase of pregnancy. ICP had considerable effect on the perinatal babyies. To further study the effect of serum glycochlicacid in diagnosis of ICP, serum glycochlicacid was measured by radiolimmunoassay in normal pregnanty women and ICP pregnant women. The determination of alanine aminotransferase(ALT) and alkaline phosphatase (ALP) were taken as contrast. Serum glycochlicacid is significantly higher ( P <0.01)in ICP pregnant women than in normal pregnant women. The positive rate of serun glycochlicacid was 100%, the positive rate of ALT was 80%, the positive rate of ALP was 40%. Serum glycochlicacid is the most sensitive serologic index in diagnosis of ICP.