不同强度跑台运动与雌激素联合作用对实验性骨质疏松大鼠骨量的影响

Effects of combination of different intensities treadmill exercise and estrogen on bone mass in experimental osteoporosis rats

目的 :将成年SD大鼠去卵巢建立骨质疏松模型 ,探讨不同强度运动与雌激素联合作用对骨质疏松大鼠骨量的影响。方法 :实验动物分基础对照组、正常对照组、阳性对照组、雌激素对照组、中等强度运动组、大强度运动组、中等强度运动 +雌激素组和大强度运动 +雌激素组。用骨形态计量学方法 ,研究了 8周的不同强度跑台运动 ,以及运动和雌激素结合对大鼠胫骨松质骨骨量的影响。结果 :中等强度运动组骨高转换受到抑制 ,骨量丢失减缓。大强度运动仍为高转换型骨代谢 ,且骨量低于中等强度运动组。两个运动加雌激素组明显抑制了去卵巢后的高骨转换 ,骨量较两个单纯运动组和雌激素对照组增多。结论

Objective:The effect of combination of different intensities exercise and estrogen on bone mass was studied in adult ovariectomized (OVX) rats. Method: Seventy female SD rats were divided into 8 groups as follow: BASAL,SHAM,OVX,OVX+ESTROGEN,OVX+EX1,OVX+EX2,OVX+DR+EX1 and OVX+DR+EX2. Histomorphometric assessment was investigated in the proximal tibial metaphysis after 8 weeks different intensities treadmill training. Result:The bone mass reduced significantly in OVX rats with increasing bone turnouver. In OVX-EX1 rats moderat exercise suppressed increased bone transformation, while high intensity exercise did not affect the histomorphometric parameters significantly compared with OVX rats,also bone formation and resorption parameters is higher significantly compared with in OVX-EX1 rats. The two combination groups had the highest bone mass in the all OVX groups and similar to BASAL, but lower than SHAM. Conclusion:Combination treatment can reduced the cancellous bone loss much more than either that of estrogen administration without exercise or exercise training without estrogen.