肺癌影像学表现、组织学类型和分化程度与p53蛋白异常表达的关系

STUDY OF THE IMAGING APPEARCE, THE HISTOLOGICAL FEATURE AND THE DIFFERENTIAL DEGREE OF LUNG CANCER AND THEIR RELATIONSHIP WITH ABNORMAL EXPRESSION OF PROTEIN P53

目的 探讨肺癌影像表现、组织学类型、分化程度与p53蛋白异常表达的关系 ,以便术前、术后更准确评估肺癌的预后。方法 对手术病理证实的 57例肺癌 ,研究其影像表现、组织学类型、分化程度与 p53蛋白阳性率 (链菌素亲生物素 -过氧化酶连接法测定 )之间的关系。结果 p53蛋白异常表达与肺癌肿块的大小、有无淋巴结转移及肿瘤的分化程度明显相关 ,而与肺癌的形态、组织学类型无明显相关。结论 肺癌的预后主要与肿瘤的大小。

Objective To study the imaging appearance, the histological feature and the differential degree of lung cancer and their relationship with abnormal expression of protein P53 so as to assess the prognosis of lung cancer more accurately. Methods 57 cases of lung cancer which were proved by pathology are collected and analyzed clinically and pathologically. Results The abnormal expression of protein P53 was relevant obviously to the dimension of the lung cancer mass, the occurrence of lymphatic metastases and its differentiation. However, it was not related to the morphic and histological features of the cancer. Conclusion The prognosis of lung cancer is mainly related to the mass dimension , the lymphatic metastasis and the differential degree.