髓母细胞瘤中P_(53)、bcl-2及Ki-67的表达及其意义

Expression and Significance of P_(53)、bcl-2 and Ki-67 Proteins in Human Medulloblastomas

用免疫组化S P法检测 2 5例髓母细胞瘤中Ki 6 7、P53 及bcl 2基因的表达。结果表明 ,在 2 5例髓母细胞瘤中 ,bcl 2和P53 蛋白的阳性表达率分别为 72 % (18/ 2 5 )和 16 % (4/ 2 5 )。Ki 6 7阳性率平均为 (33.34± 4 .98) % ,其表达与组织学分型有关。说明在髓母细胞瘤中bcl 2蛋白与P53

The expressions of Ki 67?P\-\{53\} and bcl 2 proteins were studied immunohistochemically by S P method in 25 cases of medulloblastoma. The results showed that the positive rates of bcl 2 and P\-\{53\} proteins was 72% and 16% in 25 cases of medulloblastoma respectively.The index of Ki 67 was (33.34±4.98)%, and its expression was correlated with histological type. This study indicated that the bcl 2 and P\-\{53\} probably took part in controlling cell apoptosis in medulloblastoma.