含氟牙膏用量对学龄前儿童氟摄入影响的研究

Effects of Different Quantity of Fluoride Toothpaste on Fluoride Intake by Preschool Children

目的 观察含氟牙膏 ( 10 0 0 μg/g)不同使用量对学龄前儿童氟化物摄入量的影响 ,探索学龄前儿童使用含氟牙膏较为合理、安全的用量。方法 采用离子选择性氟电极 ,测定 3个年龄组使用不同用量含氟牙膏后 2 4h尿氟排泄量 ,并以使用含氟牙膏前尿氟排泄量作为自身对照。结果 含氟牙膏用量及年龄对学龄前儿童 2 4h尿氟排泄均有显著影响 ,经SPSS统计软件包统计有显著差异。结论 学龄前儿童刷牙时因误咽部分含氟牙膏引起氟化物摄入增加 ,6岁以下的儿童 ,要减少含氟牙膏的使用量 ,每次用量不宜超过豌豆大小 (约 0 .2 5g)。

Objective This study was to investigate the influence of different quantity of fluoride toothpaste(1000μg/g) on the intake level of fluoride among three age groups of preschool children, to explore the rational and security quantity of fluoride toothpaste in preschool children.Methods Urinary fluoride excretion of 24 hour urinary samples was measured by fluoride ion electrode among three age groups of preschool children, serving 24 hour urinary fluoride excretion before using fluoride toothpaste as self control.Results There were statistically significant differences in 24 hour urinary fluoride excretion among four different quantity toothpastes( P <0.01),and among three age groups( P <0.05). Conclusion Fluoride intake level was influenced by the accidental swallowing of fluoride toothpaste among preschool children. So children under 6 year old should decrease quantity of fluoride toothpaste, no more than a small pea(about 0.25g).