咪唑安定在清醒镇静胃镜检查时最佳剂量的探讨

THE BEST DOSE OF MIDAZOLAM WITH CONSCIOUS SEDATE FOR GASTROSCOPY

目的 :探讨咪唑安定在清醒镇静胃镜检查时最佳剂量 ,并观察其对呼吸循环的影响。方法 :36 0例胃镜检查患者 (ASAⅠ～Ⅱ级 ) ,随机分为对照组 ,咪唑安定 0 .0 4mg/kg组 ,咪唑安定 0 .0 6g/kg组 ,共 3组 ,观察其镇静分级并记录脑电图双频指数分析 (BIS值 )、检查过程的遗忘程度、检查后感受情况、循环MAP ,HR及指脉血氧饱和度 (SpO2 )的变化。结果 :0 .0 6mg/kg咪啶安定组用于胃镜检查是安全有效的 ,效果明显优于未用药组和0 .0 4mg/kg组 ,镇静程度明显 ,遗忘程度高 (P <0 .0 1) ,无任何后遗症 ,对呼吸循环功能影响较小。结论 :清醒镇静胃镜检查时咪唑安定以 0 .0

Objective:To study the sedation effect and effects on Respiratory and circulatory systems of the different doses of midazolam and the best dose in gastroscopy on conseious sedation.Methods:Three hundred ad sixty outpatients undergone gastroscopy were randomyly dividend into three groups.The control group (group Ⅰ) was not given midazolam.The other two groups were intravenously given midazolam (group Ⅱ) 0.04mg/kg and (group Ⅲ)0.06mg/kg respectively.The sedative scores BIS,amnesia about the test.MAP?HR andSPO 2 were measured.Results:midazolam 0.06mg/kg could produce safe and effective sedation for gastroscopy.There were significant differences in sedative scores.amnesia and sedative degree between group Ⅲ and group Ⅱ or group Ⅰ ( P <0.05).Effects of midazolam 0.06mg/kg on respirartory and circulatory systems were small and midazolam 0.06mg/kg provided rapid recovery.Conclusions:The best dose of midazolam in gastroscopy on conscious sedation is 0.06mg/kg.